MEDLAB Middle East 2025German Exhibitors Attomol GmbH Molekulare Diagnostika

Attomol GmbH Molekulare Diagnostika

Booth number: Z6.D30
attomol.de

About us

Attomol is a steadily growing, owner-managed company with regional roots in the Lausitz region of Brandenburg and currently employs over 30 highly qualified staff. For over two decades, our company has been a developer, manufacturer and distributor of diagnostic products for laboratory medicine. Our products always serve you as reliable tools in your daily work processes. Fundamental technologies are patented by us. The focus of our work lies in the areas of:

■ Detection of mutations using allele-specific PCR and real-time PCR

■ Strip tests for the detection of autoantibodies

■ Multiplex bead assays for the detection of autoantibodies.

The face of our company is characterised by a highly competent and motivated team, which has accompanied Attomol for years on the one hand, but also continues to develop on the other. We are therefore able to provide our customers with robust and reliable test systems and also offer them expert support in working with our products. Last but not least, it is a matter of course for us to provide our customers with well-founded and quick advice.

In order to guarantee the quality of our products, we work according to a strict quality management system, certified according to EN ISO 13485: 2016. Since our products are subjected to internal and external performance evaluations within the framework of the CE marking process and are regularly checked in round-srobin tests, the requirements for quality-assured and documented production as well as sustainable quality assurance have been created. We continue to endeavour to keep all molecular genetic products IVDR-compliant on the market.

Address

Attomol GmbH Molekulare Diagnostika
Schulweg 6
03205 Bronkow OT Lipten
Germany

E-mail: info@attomol.de
Phone:  +49 35329 5906-0
Internet: attomol.de

Contact person:

Linda Dallwitz
Head of Marketing & Sales
E-mail: l.dallwitz@attomol.de

Products & Services

Laboratory Devices
Diagnostic Tests
Imaging & Diagnostics

MOLECULAR GENETICS
Mutation Assays Quicktype
Mutation Assays Realtime LoopTag
Mutations Assays Realtime TaqMan

NUCLEIC ACID EXTRACTION
Attosorb 96

IMMUNODIAGNOSTICS
Autoantibody Lineassay
Autoantibody Beadassay

DEVICE - fluorescence imager
Caleidoscan 100
Caleidoscan 300

Quicktype

By the use of our well-established Quicktype mutation assays samples can be analyzed for genetic polymorphisms in a fast and user-friendly way. Our assays find the application in routine diagnostics for thrombophilia, metabolism, immunogenetics and pharmacogenetics.

To differentiate genotypes our Quicktype assays use an allele-specific PCR with integrated probe hybridization. The separation of amplification products is performed directly after the PCR without any additional incubation steps either by agarose gel electrophoresis or by automatic capillary electrophoresis. The resulting band pattern reveals the genotype of the patients sample. A low-molecular PCR product shows the wild type allele, a higher-molecular PCR product shows the mutated allele.

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evaluation by gel electrophoresis

testkit Quicktype

LoopTag

For the diagnostic fields of thrombophilia, metabolism and immunogenetics we offer Realtime LoopTag (LT) PCR assays for the detection of disease-related polymorphisms in the human genome. That quick and certain method assures the reliable genotyping of patient samples. The tests of the product line Realtime LT are compatible with our nucleic acid extraction kit Attosorb 96.

After the isolation of DNA from patient’s blood the target sequence is amplified within a single reaction mixture. The detection of amplification products is performed by the hybridization of specific LoopTag probes1). The definite identification of the sample’s genotype is made by a melting curve analysis after the amplification.

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evaluation by melting curves

testkit LoopTag

TaqMan

For the detection of disease-related polymorphisms in the human genome in the diagnostic fields of thrombophilia, metabolism and immunogenetics we also offer real-time PCR assays based on TaqManTM technology. That quick procedure assures reliable genotyping of patients samples on various devices. The tests of the product line Realtime TM are compatible with the nucleic acid extraction kit Attosorb 96.

After the isolation of DNA from patient's blood the target sequence is amplified within a single reaction mixture. The specific TM probe is degraded through the 5`-nuclease activity of the polymerase in each amplification cycle. The released fluorescent dyes can be detected in the corresponding channel of a real-time cycler. The evaluation is performed either by the direct analysis of amplification curves or easily interpretable scatter plot.

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evaluation by scatter plot

testkit TaqMan

Attosorb 96

Attosorb is a system for DNA purification, developed and patented by Attomol, in which the DNA of a blood sample of a patient binds directly to the cavity of a PCR microplate. In contrast to conventional DNA extraction systems, the molecular genetic detection through PCR is performed in the same cavity afterwards. Therefore this easy and time-saving procedure can only be used together with our tests of the attomol product lines Realtime LT and Realtime TM.

Coagulation inhibited whole blood is pipetted into a PCR microplate and is lysed afterwards. The DNA of the blood sample binds to the solid phase of the PCR microplate and the excess materials are washed out. The remaining liquid of the washing solution is dried after the last washing step to standardize the reaction conditions for the following PCR. Afterwards the PCR is performed in the same microplate.

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flow chart Attosorb 96

testkit Attosorb 96

Beadassay

The antibody Beadassay was developed as a semiquantitative multi-parameter testing system for the simultaneous detection or differentiation of antibodies in patients sera. In comparison to line blots it is more precise, has a wider dynamic measuring range and can be automatically processed. The multiparameter function of the microplate-based antibody Beadassay makes it possible to detect several analytes in one reaction vessel as well as to integrate various controls to increase test reliability and its precision.

The antibody Beadassay is a fluorescence-based assay. Specific antigens are bound at up to 18 size- and fluorescence-coded beads. The beads carrying antigens are permanently immobilized at the bottom of a well on a common 96-well microplate (12 modules, 8 wells each) adhering to the solid phase inbetween various steps of incubation. In case of positive samples the antibodies from the patient‘s serum bind to the relevant beads during the incubation. After the incubation with a secondary fluorescence-coded human specific antibody the fluorescent beads are measured with Caleidoscan 100. In consideration of the detected sizes and fluorescence of the beads the exact allocation of the antigens and the positive or negative determination takes place by decoding the beads.

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evaluation of the beads

testkit Beadassay

Caleidoscan 300

The attomol® Caleidoscan 300 (CS300) is the further developed version of the attomol® Caleidoscan 100 (CS100). Like CS100, it is a automated fluorescence imager with three measuring channels, which is used for imaging fluorescent microobjects, such as fluorescence and size-coded microparticles (beads) in attomol® bead assays. The CS300 is driven by the attomol® Caleidopro control and analysis software. Compared to flow cytometric measurement methods, the CS100 and CS300 are significantly faster. The evaluation of 32-wells by CS300 only takes approx. 5 minutes. The measuring system is characterized by a large linear measuring range and high precision.

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Caleidoscan 300

antibody avidity

The caleidoscan generates automated and standardized measurement and processing of beadassays with high reliability and accuracy by microscope precession optics during rapid thermocycling or melting curve analysis by the thermocycler Caleidoamp100. Addiotionally high safety due to internal controls in each microplate well fast measurement of 32 wells in approx. 5 min.

Caleidoscan 300 records images of fluorescence- and size-encoded microparticles (beads) of antibody bead assays simultaneously to heating and cooling of Caleidoamp 100. Caleidoscan 300 and Caleidoamp 100 are controlled by the software Caleidopro that also performs data processing.

  • automated Real-time antibody melting curve analysis of antibody beadassays

  • Melting point determination is based on non-linear regression models

  • applicable to patient’s serum antibodies as well as to monoclonal or recombinant antibodies

antibody avidity testing by melting curve analysis

melting curve of recombinant antibodies

melting curve of antibodies from human sera

Caleidoscan 100

The attomol® Caleidoscan 100 (CS100) is an automated fluorescence measuring device which is used for imaging recording of fluorescent micro objects, e.g. fluorescence and size coded micro particles (beads) when measuring attomol® Beadassays . The CS100 is controlled by the control and evaluation software attomol® Caleidopro (CP). Compared to flow cytometric measurement methods the CS100 is much faster.

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Caleidoscan 100

working plate of Caleidoscan 100

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